Emkhakheni we-biotechnology kanye ne-biopharmaceutical, amagama athi "bioreactor" nelithi "biofermenter" avame ukusetshenziswa ngokushintshana, kodwa abhekisela kumasistimu ahlukene anemisebenzi ethile kanye nezicelo. Ukuqonda umehluko phakathi kwalezi zinhlobo ezimbili zemishini kubalulekile kochwepheshe kulo mkhakha, ikakhulukazi lapho beklama futhi bekhiqiza izinhlelo ezihlangabezana nezindinganiso eziqinile zokulawula.

Ukuchaza Imigomo

I-Bioreactor igama elibanzi elihlanganisa noma yisiphi isiqukathi lapho ukusabela kwebhayoloji kwenzeka. Lokhu kungabandakanya izinqubo ezihlukahlukene njengokuvutshelwa, isiko lamaseli, nokusabela kwama-enzyme. Ama-Bioreactors angakhelwa izimo ze-aerobic noma anaerobic futhi angasekela izinhlobonhlobo zezinto eziphilayo, okuhlanganisa amagciwane, imvubelo, namaseli ezincelisayo. Zihlonyiswe ngezinga lokushisa elihlukahlukene, i-pH, izinga le-oxygen, nezilawuli zokuyaluza ukuze kuthuthukiswe izimo zokukhula zama-microorganisms akhulisiwe noma amaseli.

I-biofermenter, ngakolunye uhlangothi, iwuhlobo oluthile lwe-bioreactor olusetshenziswa ngokuyinhloko ezinqubweni zokuvutshelwa. Ukuvutshelwa kuyinqubo ye-metabolic esebenzisa ama-microorganisms, ngokuvamile imvubelo noma amagciwane, ukuguqula ushukela ube ama-asidi, amagesi, noma utshwala.Ama-Biofermenters zenzelwe ukudala indawo evumelana nokukhula kwalezi zinambuzane ezincane, ngaleyo ndlela zikhiqize imikhiqizo ehlukahlukene efana ne-ethanol, i-organic acid, kanye nemithi.

Umehluko Oyinhloko

Umsebenzi:

Ama-Bioreactors angasetshenziselwa izinqubo ezihlukahlukene ze-bioprocesses, okuhlanganisa isiko lamaseli kanye nokusabela kwe-enzyme, kuyilapho ama-fermenters enzelwe izinqubo zokuvutshelwa.

Imininingwane yedizayini:
Ama-Biofermentersngokuvamile aklanywa ngezici ezithile ukuze ahlangabezane nezidingo zezinto eziphilayo ezibilayo. Isibonelo, zingabandakanya izici ezifana nama-baffles ukuthuthukisa ukuxutshwa, amasistimu athile omoya wokuvutshelwa kwe-aerobic, kanye nezinhlelo zokulawula izinga lokushisa ukuze kugcinwe izimo zokukhula ezifanele.

Isicelo:
Ama-Bioreactors ahlukahlukene kakhulu futhi angasetshenziselwa izinhlelo zokusebenza ezahlukahlukene ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, ukudla neziphuzo, kanye ne-biotechnology yezemvelo. Ngokuphambene, ama-fermenters asetshenziswa ngokuyinhloko ezimbonini ezikhiqiza imikhiqizo yokuvutshelwa, njengokwenza iwayini, ukuphisa, nokukhiqizwa kwe-biofuel.

Isikali:
Kokubili ama-bioreactors nama-fermenters angaklanywa abe nezikali ezihlukene, kusukela ocwaningweni lwaselabhorethri kuya ekukhiqizweni kwezimboni. Kodwa-ke, ama-fermenters avame ukuba namandla amakhulu okuthwala inani elikhulu lomkhiqizo ovame ukukhiqizwa ngesikhathi sokuvutshelwa.

Iqhaza le-GMP ne-ASME-BPE ekwakhiweni kokuvutshelwa

Ukuhambisana nezindinganiso zokulawula kubalulekile uma kuziwa ekwakhiweni nasekukhiqizeniama-bio-fermenters. Kwa-VENN, siqinisekisa ukuthi ama-fermenters ethu aklanywa futhi akhiqizwa ngokuhambisana ngokuqinile nemithetho ye-Good Manufacturing Practice (GMP) kanye nezimfuneko ze-ASME-BPE (American Society of Mechanical Engineers - Bioprocessing Equipment). Lokhu kuzibophezela kwikhwalithi nokuphepha kubalulekile kumakhasimende ethu e-biopharmaceutical athembele kumishini yethu ukuze avubele isiko le-microbial.

Eyethuamathangi okuvutshelwaifaka imiklamo yobungcweti, esebenziseka kalula kanye ne-modular engahlanganiswa kalula kumasistimu akhona. Sinikeza imikhumbi ethobelana namazinga ahlukahlukene emikhumbi yengcindezi kazwelonke, okuhlanganisa i-ASME-U, i-GB150 ne-PED (Isisetshenziswa Sokucindezelwa Kwezinto Zokucindezela). Lokhu kuguquguquka kuqinisekisa ukuthi amathangi ethu angakwazi ukwamukela izinhlobonhlobo zezicelo kanye nezidingo zokulawula.

Ukwenza ngokwezifiso kanye nokuhlukahluka

Kwa-VEN, siyaqonda ukuthi ikhasimende ngalinye le-biopharmaceutical linezidingo ezihlukile. Kungakho sinikeza uhla olugcwele lokuvutshelwa kokutshalwa kwe-microbial, kusukela elabhorethri ye-R&D ukuya ekuhlolweni kokuhlola kanye nokukhiqizwa kwezimboni. Ama-fermenters ethu angenziwa ngokwezifiso ezidingweni ezithile, okuhlanganisa umthamo, kusukela kumalitha angu-5 kuya ku-30 kiloliters. Lokhu kuvumelana nezimo kusivumela ukuba sihlangabezane nezidingo zamabhaktheriya asebenza kakhulu, njenge-Escherichia coli ne-Pichia pastoris, avame ukusetshenziswa ekukhiqizeni i-biopharmaceutical.

Ngamafuphi, kuyilapho kokubili ama-bioreactors kanyeama-biofermenterszidlala indima ebalulekile emkhakheni we-biotechnology, zisetshenziselwa izinhloso ezehlukene futhi zenzelwe imisebenzi eyahlukene engqondweni. Ukuqonda lo mehluko kubalulekile ekukhetheni izisetshenziswa ezifanele zohlelo oluthile. Kwa-VENN, sizibophezele ekuhlinzekeni ama-fermenters ekhwalithi ephezulu ahlangabezana nezidingo eziqinile zemboni ye-biopharmaceutical, siqinisekisa ukuthi amakhasimende ethu angathola imiphumela engcono kakhulu ezinqubweni zawo zokutshala amagciwane. Noma ngabe usesigabeni sokuqala socwaningo noma ukhuphula ukukhiqizwa kwezimboni, ubuchwepheshe bethu kanye nezixazululo ozenza ngokwezifiso zingakusiza ukuthi uzulazule ngokuzethemba ezinkingeni ze-bioprocessing.