Inani elikhulu lama-buffers liyadingeka kwinqubo eyayisehlaselweni yokuhlanza ama-biopharmaceuticals. Ukunemba kanye nokuvela kabusha kwama-buffers kunomthelela omkhulu kwinqubo yokuhlanzwa kwamaprotheni. I-dilution eku-inthanethi kanye nohlelo lwe-inthanethi lwe-inthanethi lungahlanganisa izinhlobo ezahlukene ze-buffers eyodwa. Utshwala bomama kanye ne-dilount kuxutshaniswe online ukuthola isixazululo esiqondiwe. Umkhiqizo ususelwa olwazini lwesayensi, futhi ikhwalithi ivela emcabangweni we-Design (QBD). Ngokusebenzisa i-inthanethi yangempela online (yangempela ngesikhathi) Ukuqapha kanye nokulawula izinkomba ezimbili zamakhemikhali, izimfanelo ezisezingeni elifanele (CQA) zomkhiqizo (CQA), ph. Inqubo yokulungiselela uketshezi yendabuko idinga inani elikhulu lamathangi nevolumu enkulu. I-INEVEL eletha amakhasimende isipiliyoni sezobuchwepheshe esisha, ehlisa isipesheli se-buffer dosing esiteji senqubo yokuhlanzwa, futhi anciphise ukutshalwa kwezimali kwangaphambi kokutshala kanye nokukhiqizwa kwangemva kokukhiqizwa kanye nezindleko zokusebenza. , Thuthukisa ukusebenza kahle kokukhiqizwa, qiniseka ukuthi amapharamitha abucayi wenqubo (i-CPP) ye-buffer kanye nokulandelwa kwawo, futhi ekugcineni athuthukise ikhwalithi yemithi.